The results showed that after transfection with B7‐H3 shRNA, the expression levels of mesenchymal cell‐characterizing proteins, N‐cadherin and Vimentin, were significantly decreased, while expression of the epithelial cell‐characterizing protein, E‐cadherin, was increased, indicating that B7‐H3 knockdown could significantly inhibit the occurrence of EMT in NPC cells (Figure 2C,D). The gene discussed is CD276; the disease is nasopharyngeal carcinoma.