To further explore whether B7‐H3 suppression in NPC cells affected tumor growth in vivo, we constructed cell lines with stable knockdown of B7‐H3 expression and subcutaneously inoculated nude mice with 5 × 106 stable sh‐NC‐transfected cells or stable sh‐B7‐H3‐transfected cells to create xenograft tumor models. This evidence concerns the gene CD276 and nasopharyngeal carcinoma.