Some of the mechanisms in which Nicotine in cigarettes may be involved in HS pathogenesis include inducing infundibular epithelial hyperplasia and hyperkeratosis, altering the cutaneous microbiome, stimulating release of TNF by keratinocytes and T‐helper 17 cells, disturbing polymorphic neutrophil granulocyte chemotaxis, and immunomodulating macrophage function.43 This evidence concerns the gene TNF and Hyperkeratosis.