HIC1 and neoplasm: Module 2 was organized by mesenchymal progenitor cells, osteoblast progenitor cells and fibroblast, including DBP, PRRX2 [83] which participated in mesenchymal cell differentiation, HIC1 [65] which transformed mesenchymal stem cells into tumor stem cells, SP7 [79] which was involved in osteogenic and chondrogenic differentiation from MSCs, TWIST1 and FOXD1 [84] which was a regulator of osteoblast differentiation.