In addition to these functions, CD155 also has an immunomodulatory role, promoting immune evasion by interacting with certain receptors on CD8 + T and Natural Killer (NK) cells, including T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) and Cluster of Differentiation 96 (CD96), DNAX accessory molecule-1 (DNAM-1) which ultimately downregulate production of interferon gamma (IFNγ) and interleukine-2 (IL-2) [4], promote the secretion of IL-10 by dendritic cells [5], and suppress cell-dependent cytotoxic responses against cancer cells [6]. The gene discussed is PVR; the disease is cancer.