Human UHRF1 (also known as ICBP90) was initially discovered as a regulator of TopoIIalpha [12, 13], which is an oncogene that is overexpressed in a variety of solid and hematological tumors [14], including hepatocellular carcinoma [15], lung cancer [16, 17], and colorectal cancer [18]. Here, UHRF1 is linked to colorectal cancer.