STIP1 homology and U-Box containing protein 1 (STUB1), formerly known as CHIP (C-terminus of HSC70-Interacting Protein), is a chaperone-dependent E3 ubiquitin ligase that plays an essential role in various aspects of cancer, including tumorigenesis, progression, metastasis, drug resistance, and patient prognosis [25, 26]. The gene discussed is STUB1; the disease is cancer.