In line with the recombinant protein interactions, we found that ADNP of IE expressing ICAM-1 + EPCR binding IE (that contain DBLβ3_Pfd1235w) was elevated in uncomplicated malaria compared to cerebral malaria, in keeping with the published associations between ICAM-1 + EPCR binding PfEMP1 types and cerebral malaria [6]. Here, ICAM1 is linked to malaria.