Children with cerebral malaria had higher ADCP of ICAM-1 + EPCR binding IE compared to children with uncomplicated malaria (10% (6–15%) and 6% (2–9%), respectively, p = 0.001) and there was no statistically significant difference in THP-1 cell phagocytosis of ICAM-1 + CD36 binding IE between children with cerebral and uncomplicated malaria (9% (1–22%) and 5% (1–15%), respectively, p = 0.52). Here, ICAM1 is linked to cerebral malaria.