ZMIZ2 and neoplasm: Subsequent colony assays, transwell, and MTT assays revealed that ZMIZ2 overexpression enhances the colonic (NCI-H1299, empty vector versus ZMIZ2: 35 ± 4 versus 68 ± 5, P = 0.0059), invasive (NCI-H1299, empty vector versus ZMIZ2: 25 ± 4 versus 63 ± 5, P = 0.0030), and proliferative capabilities (NCI-H1299, empty vector versus ZMIZ2: 1.072 ± 0.054 versus 1.372 ± 0.084, P = 0.0173) of tumor cells (Fig. 2A, C, E).