ZMIZ2 and neoplasm: Conversely, ZMIZ2 knockdown significantly inhibited malignant phenotype of the tumor (Calu-1: colony assay: sg-control versus sg-ZMIZ2-1: 97 ± 7 versus 58 ± 5, P = 0.0118; sg-control versus sg-ZMIZ2-2: 97 ± 7 versus 46 ± 6, P = 0.0054; transwell assay: sg-control versus sg-ZMIZ2-1: 66 ± 5 versus 26 ± 4, P = 0.0028; sg-control versus sg-ZMIZ2-2: 66 ± 5 versus 28 ± 7, P = 0.0109; MTT assay: sg-control versus sg-ZMIZ2-1: 1.089 ± 0.099 versus 0.748 ± 0.039, P = 0.0130; sg-control versus sg-ZMIZ2-2: 1.089 ± 0.099 versus 0.620 ± 0.074, P = 0.0056) (Fig. 2B, D, F).