As a result, the following parameters were observed: (1) localization: ZMIZ2 was localized within the nuclei of human immortalized bronchial epithelial cells and lung cancer cells; (2) expression profile: ZMIZ2 was expressed at low levels in bronchial and alveolar epithelial cells of normal lung tissue (10/32), but was highly expressed in multiple lung cancer cell lines (5/7) and observed in over 59.14% (55/93) of NSCLC cases. This evidence concerns the gene ZMIZ2 and non-small cell lung carcinoma.