Glu level (OR = 1.117, 95% CI = 1.032–1.210, P = 0.006), TBA (OR = 2.898, 95% CI = 1.946–4.315, P = 0.000), PCT (OR = 1.004, 95% CI = 1.001–1.008, P = 0.005) and TNF-α (OR = 1.091,95% CI = 1.011, 1.177) were independent prognostic risk factors for pediatric sepsis. The gene discussed is TNF; the disease is Sepsis.