Biomarkers with high sensitivity and specificity, such as interleukin-8 (IL-8), C-reactive protein (CRP), procalcitonin (PCT), D2 polymer(D-dimer), presepsin, brain natriuretic peptide, lactate (Lac), activated partial thromboplastin time (APTT), endocan, and monocyte chemotactic protein-1 (mcp-1) each possible pediatric sepsis biomarkers have their own characteristics and application differences. The gene discussed is CRP; the disease is Sepsis.