The final results showed that pH (OR = 0.003, 95% CI = 0.000–0.121, P = 0.002), ALB (OR = 0.923, 95% CI = 0.862–0.988, P = 0.021), and CK-MB (OR = 0.996, 95% CI = 0.992–0.999) were protective factors for the prognosis of sepsis. This evidence concerns the gene ALB and Sepsis.