Further, these genes were found to be involved in various pathways, including metabolic pathways, calcium signaling pathways, ubiquitin-mediated proteolysis, apoptosis, spliceosome, as well as many cancer-related signaling pathways like hippo, HIF-1, PI3K-Akt, and Shh signaling pathways (Fig. S6b, Table S3). Here, SHH is linked to cancer.