JAML and infection: Conversely, epithelial cell-specific CCV-colocalizing cCRE was linked to epithelial cell-preferential expressed genes including MPZL3, which is adjacent to JAML. JAML encodes a junctional adhesion molecule playing a role in defense against infection, tissue homeostasis and repair, and inflammation in the tissue-resident gamma-delta T cells at the epithelial barrier46,47, suggesting its potential roles in lung tumorigenesis through interplay with epithelial cells.