Recurrent somatic mutations in PIK3CA, FBXW7, MAPK1, PTEN, EP300, NFE2L2, CASP8, STK11, HLA-A, and HLA-B are enriched in SCC, while in ADC, ELF3, CBFB, KRAS and ARID1A are enriched4,5. The gene discussed is EP300; the disease is AIDS dementia complex.