MAPK1 and AIDS dementia complex: Hotspot mutations FBXW7 R505G (2.9%) and STK11 c.290+1 G > A (2.9%) were the next most common in ADC, while for SCC, the next most common mutations were EP300 D1399N (4.8%) and MAPK1 E322K (4.8%) Fig. 3.