These alterations in NF have been found to precede neurodegeneration (Wilson et al., 2016; Krasemann et al., 2017) and cognitive decline (Vickers et al., 1994; Bussière et al., 2003; Thangavel et al., 2009) both in aging and Alzheimer's disease. The gene discussed is NFASC; the disease is Alzheimer disease.