To do so, we first checked the expression levels of CRLR and RAMPs in cancer cell lines, which are capable of metastasizing to bone (human prostate cancer cell lines: LNCaP, PC-3, and DU145; human breast cancer cell lines: MCF-7, MDA MB-231, and ZR75-1; human lung cancer cell lines: A549 and SK-MES-1; and human prostate epithelial cell line: PWR-1E). This evidence concerns the gene CALCRL and lung cancer.