Aggregates of α-synuclein (α-syn) protein are a pathological hallmark of the “synucleinopathies”, neurodegenerative diseases which include Parkinson’s disease (PD) and related disorders such as dementia with Lewy bodies (DLB) and multiple system atrophy (MSA) [1,2]. The gene discussed is SNCA; the disease is multiple system atrophy.