TLR4 and obesity due to melanocortin 4 receptor deficiency: Prediction of lipopolysaccharide (LPS) as a potential regulator activated in C is coherent as LPS-induced signalling is known to contribute to the pro-inflammatory milieu in human obesity and to trigger the production of reactive oxygen and nitrogen species, such as through TLR4-mediated NADPH oxidase activation in macrophages [67].