In agreement, several pathways involving alterations in insulin signalling (insulin secretion signalling, insulin receptor signalling, insulin resistance, Type I and Type II diabetes mellitus signalling pathways) and others that have been found to enhance insulin resistance in obesity (such as the adipocyte CREB/CRTC pathway) [58] were activated in C (S6 Table). Here, CALR is linked to obesity due to melanocortin 4 receptor deficiency.