In agreement, several pathways involving alterations in insulin signalling (insulin secretion signalling, insulin receptor signalling, insulin resistance, Type I and Type II diabetes mellitus signalling pathways) and others that have been found to enhance insulin resistance in obesity (such as the adipocyte CREB/CRTC pathway) [58] were activated in C (S6 Table). This evidence concerns the gene CALR and type 2 diabetes mellitus.