The genes with higher relative frequency of SCNAs in the cfDNA and the tumor samples were: BRCA1(50%), CDK12 (50%), NF1 (46%), MAP2K4(42%), NCOR1 (42%), TP53 (42%), KEAP1 (33%), STK11 (33%), CTCF (33%), CHEK2 (29%), EP300 (29%), and PRKAR1A (29%) (Fig 6). This evidence concerns the gene PRKAR1A and neoplasm.