However, we speculate that the mechanism responsible for these observed multinucleated fibers is not the same as in centronuclear myopathies caused by mutations in BIN1, MTM1, or DNM2, as classically those result in the persistence of myofibers with a single, well-centralized nucleus (72, 73). This evidence concerns the gene BIN1 and autosomal dominant centronuclear myopathy.