However, we speculate that the mechanism responsible for these observed multinucleated fibers is not the same as in centronuclear myopathies caused by mutations in BIN1, MTM1, or DNM2, as classically those result in the persistence of myofibers with a single, well-centralized nucleus (72, 73). The gene discussed is MTM1; the disease is autosomal dominant centronuclear myopathy.