TLR3 and pancreatitis: As shown in this study, the initial event causing pancreatitis in the MRL/MpJ model is most likely IFN-α/β production by pancreatic tissue–resident TLR3-bearing cDCs stimulated by a disease-inducing TLR3 ligand such as poly(I:C), rather than IFN-α/β production by stimulated TLR7/9-bearing pDCs.