By flow cytometric analysis of PMNCs from mice subjected to TLR3 blockade and control mice (Supplemental Figure 2A), we also found that blockade of TLR3 signaling led to a great reduction in the cellular immune response previously shown to cause AIP, i.e., a reduction in the pancreatic accumulation of pDCs (defined as PDCA-1+B220lo cells) and CD3+ T cells (Figure 1C). The gene discussed is TLR3; the disease is autoimmune pancreatitis.