IL33 and pancreatitis: A key finding was that inflamed pancreatic tissue in this model was replete with plasmacytoid dendritic cells (pDCs) producing IFN-α and IL-33 and that depletion of these cells or blockade of IFN-α– or IL-33–mediated signaling pathways almost completely protected the mice from the development of pancreatitis and its fibrotic sequelae (3–6).