Recognizing that poly(I:C) activation of TLR3 in cDCs residing in the uninflamed pancreas and then in the nascent inflamed pancreas would induce production of type I IFNs and Th1 chemokines (CXCL9, CXCL10), we reasoned that poly(I:C) induction of AIP could be accompanied by an early downstream Th1 cell–oriented cytokine and chemokine response that could lead to induction of Th1 cells in lymph nodes draining the pancreas and their migration into the pancreas. This evidence concerns the gene TLR3 and autoimmune pancreatitis.