STING1 and STING-associated vasculopathy with onset in infancy: De novo gain-of-function mutations in STING underlie STING-associated vasculopathy (SAVI), an autoinflammatory interferonopathy characterized by acral vasculitis, recurrent fever, and interstitial lung disease due to constitutive type I IFN signaling even in the absence of cGAMP stimulation [25].