Typical cases with clear cell morphology may be difficult to distinguish particularly from the TFE3-rearranged PEComa subtype, which is composed of similar looking clear cells and has a similar immunophenotype (TFE3 gene belongs to the same MIT/TFE signaling pathway as MITF). The gene discussed is TFE3; the disease is neoplasm with perivascular epithelioid cell differentiation.