Annual WB-MRI is not recommended for every individual; however, it might be indicated in selected high-risk constellations, such as confirmed atypical neurofibromatous neoplasm with uncertain biological potential (ANNUBP) [23], a high internal tumor burden detected by WB-MRI at HCT or high-risk genetic constellations, such as NF1 microdeletions that affect the entire NF1 gene and several flanking genes or a full deletion of the NF1 gene [24]. This evidence concerns the gene NF1 and neoplasm.