The majority of the studies that focused on this inflammation marker found associations between high levels of GFAP and lower WM in temporal and parietal areas [67], lower temporal cortical thickness and WMH only in Aβ-PET positive cases [78], and altered levels of mIns, a marker of astrocytic function, in a brain area particularly affected by AD, i.e., the PCC/precuneus [53]. The gene discussed is GFAP; the disease is Alzheimer disease.