MAPT and Alzheimer disease: Beta-amyloid (Aβ) markers (e.g., Aβ42/40 ratio), phosphorylated tau (p-tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) are among the most advanced BBM for AD-relevant diagnostic and prognostic purposes [8], with p-tau showing high specificity and NfL having high sensitivity values.