Moreover, Verde et al. [18] provided a short review on the association between p-tau isoforms and neuroimaging features, highlighting that plasma p-tau181 levels are negatively correlated (mainly in Aβ-positive individuals) with whole brain volume as well as GM volumes of several temporo-parietal areas (i.e., hippocampus, entorhinal cortex, precuneus, and posterior cingulate cortex), cortical thickness of the temporal lobe and of an AD-signature region, and fractional anisotropy (FA) values in the genu of the corpus callosum. Here, MAPT is linked to Alzheimer disease.