To examine the properties of VIP/CR-coexpressing I-S3 cells in AD-afflicted mice, we generated VIP-eGFP-3xTg (VIP-Tg) mice by crossing homozygous 3xTg-AD (Tg) with VIP-eGFP (VIP-nonTg) mice, in which all INs immunoreactive for VIP express eGFP (Tyan et al., 2014). The gene discussed is VIP; the disease is Alzheimer disease.