APP and Alzheimer disease: The 3xTg-AD (Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax) mouse model, combining three familial AD mutations (Swedish APP KM670/671NL, PSEN1 M146V, and MAPT P301L) exhibits accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles, synaptic impairment, and cognitive deficits (Javonillo et al., 2021).