Spatiotemporal profiling of CM-specific ADGRG1 expression within the heart normally and during the development and progression of HF would be informative since our scRNASeq analysis revealed that ∼20% of CMs express ADGRG1 in healthy hearts, which is reduced 10-fold, down to ∼2% of CMs in mice that progressed to HF in the pressure overload model. Here, ADGRG1 is linked to hydrops fetalis.