TFEB is an important transcription factor that regulates the lysosomal response to cellular stimuli and modulates lysosome‐related genes, including TRPML1.[25, 42] Previous studies have reported that TFEB regulates lysosomal exocytosis through TRPML1.[28] To determine whether TFEB is involved in depression‐related stress, we first examined TFEB protein levels in the mPFC of C57BL/6J mice after the CSDS paradigm using Western blotting. This evidence concerns the gene MCOLN1 and depressive disorder.