MCOLN1 and depressive disorder: [45] Our findings, together with previous studies, indicate that the dysfunction of astrocytic lysosomes, including lysosomal exocytosis, acidification and phagocytosis, plays an important role in depression.[46, 47] Here, we found that chronic stress alters the morphology of astrocytic lysosomes and the expression of astrocytic TRPML1 and TFEB (Figures 1 and 5).