In a comprehensive survey of 1793 Chinese LHON probands, three Han Chinese families were identified, each carrying both tRNAGlu 14693A > G and ND6 m.14484T > C mutations.[8, 21, 44] Among 37 matrilineal relatives in these families, 17 exhibited varying degrees of penetrance and expression of optic neuropathy, with the severity of vision loss ranging from profound to severe (Table S1, Supporting Information; Figure 1A,B). This evidence concerns the gene MT-ND6 and Optic neuropathy.