Univariate analysis revealed that tumor depth, lymph node metastasis, stage, lymphatic invasion, venous invasion, infiltration of CD8 and FOXP3, PD‐L1 TC, CD25, CD4+CD25+FOXP3+ Tregs, and the CD8+ TILs/CD4+CD25+FOXP3+ Tregs ratio were significantly associated with OS. This evidence concerns the gene CD4 and metastatic malignant neoplasm in the lymph nodes.