CD274 and neoplasm: In the multivariate analysis, tumor depth (HR: 0.303, 95% CI: 0.116–0.790, p = 0.015), CD8 infiltration (HR: 4.319, 95% CI: 1.386–13.454, p = 0.012), and PD‐L1 TC (HR: 0.455, 95% CI: 0.220–0.943, p = 0.034) were independent prognostic factors for ESCC (Table 4).