Although several signaling pathways have been implicated in the pathogenesis of FEVR, variants in crucial components of Norrin/β-catenin signaling account for most of the FEVR cases (Junge et al., 2009; Zhu et al., 2021; Panagiotou et al., 2017). Here, NDP is linked to Familial exudative vitreoretinopathy.