Chromosome 21 encodes four subunits of IFN receptors (IFN-Rs): IFNAR1, IFNAR2, IFNGR2 and IL10RB. The 1.5-fold increase in copy number of IFNAR1 and IFNAR2 found in individuals with DS has been shown to be an important factor in neurodegenerative, endocrine, renal and gastrointestinal disorders with common autoimmune etiologies of the syndrome (Jagadeesh et al., 2020; Malle and Bogunovic, 2021). Here, IFNAR1 is linked to digestive system disorder.