In the cell culture assay, using PBMCs, mRNA levels for the NLRP1, NLRP3 and IL-1β genes (Figure 2) among individuals with DS (n=10), were downregulated for NLRP1 +1.7 FC (p=0.1879), and an upregulation for NLRP3 and IL-1β genes of +1.4 FC (p=0.5889) and +5.4 FC (p=0.0075), respectively, when comparing cells treated with LPS stimulation in relation to cells that did not receive the stimulus. The gene discussed is IL1B; the disease is Dravet syndrome.