Individuals with hypothyroidism (n=9) (Figure 3 a ), the mRNA levels showed an upregulation for NLRP1 gene of +1.0 FC (p=0.7912), and a downregulation of the NLRP3 and IL-1β genes of +1.1 FC (p=0.4785) and +1.4 FC (p=0.3005), respectively, when compared with individuals without hypothyroidism (n=11). Here, IL1B is linked to hypothyroidism.