The fibroblast population overexpressed in DFU‐healed patients is designated HE‐Fibro, and in‐depth analysis of its subpopulation reveals that high expression of genes related to ECM remodelling (MMP1, MMP3) and immunity/inflammation (CHI3L1, TNFAIP6) is conducive to ulcer wound healing. The gene discussed is CHI3L1; the disease is ulcer disease.