Based on the important role of immune cells in the occurrence and progression of DFU, Gan et al. analysed the cell abundance of DM, DFU healing, and DFU non‐healing, and found that immune cells (activated CD8+ T cells, central memory CD8+ T cells, T follicular helper cells, myeloid suppressor cells, NKT cells and monocytes) were highly infiltrated in patients with non‐healing DFU. The gene discussed is CD8A; the disease is diabetes mellitus.