Voxel‐wise t‐tests revealed significantly higher tau binding in AD compared to controls in frontal and posterior cortical areas (occipital, parietal, temporal) (p < 0.001, FDR corrected, k > 500), and significantly more tau binding in posterior cortical regions compared to 4RT (p < 0.001, FDR corrected, k > 500). This evidence concerns the gene MAPT and Alzheimer disease.