In the era of PDAC, two recent published studies have linked SDC1 levels with mutated overexpressed KRAS, the initiating step in most PDACs, which cooperate to induce a malignant phenotype through regulation of macropinocytosis, a critical metabolic pathway that fuels PDAC cell growth and promotes tumor progression.18, 19. The gene discussed is SDC1; the disease is neoplasm.