CD4 and neoplasm: developed an anti‐tumor vaccine based on a square‐block DNA origami hybridized with CpG strands as the adjuvant and ovalbumin (OVA) proteins as the antigen.[75] Upon subcutaneous (s.c.)injection to tumor‐bearing mice, this origami accumulated in the nearest draining lymph nodes and activated dendritic cells, CD8 T+ cells, Th1‐polarized CD4+ cells, and natural killer cells.