TNF and cancer: patterned multiple tumor necrosis factor (TNF)‐related apoptosis‐introducing ligand (TRAIL)‐mimicking peptides, a ligand of death receptors 4 and 5 on cancer cells, in the form of a hexagonal array with varying interpeptide spacing on a 2D DNA origami nanostructure.[249] The authors identified 5 nm as the most suitable interpeptide distance for inducing death receptor clustering and apoptosis, offering insights into NP‐receptor interaction.