NUCLEOLIN and neoplasm: reported a DNA origami nanotube (90 nm × 19 nm) that contains thrombin as the drug to trigger thrombosis (which deprives the tumor of nutrients) in its core, DNA aptamers to target nucleolin on tumor vessels on its surface, and fastener strands that relax the nanotube to its original rectangular origami structure upon contact with nucleolin (Figure 7a).[171] Upon i.v. injection into orthotopic tumor‐bearing mice, the nanotubes entered CD34‐expressing ECs (Figure 7b) and released thrombin to induce vessel infarction and tumor necrosis.