In our proof‐of‐concept studies, we attached noncoding polythymidine DNA oligonucleotides to a PEG‐coated superparamagnetic iron oxide NP (PEG‐SPION) to construct a DNA‐based SNA (DNA‐SPION).[140] Upon i.v. injection into apolipoprotein E knockout (ApoE–/–) mice fed on a high‐cholesterol diet, an established disease model of atherosclerosis, the DNA‐SPIONs accumulate in the aorta and aortic root (the primary sites of plaques) more rapidly and abundantly than PEG‐SPIONs. Here, APOE is linked to atherosclerosis.