Nutritional status seems to be a key factor for the diagnosis of COVID-19, since obesity is related to low-grade inflammation, with a decrease in immune response, increases the risk of serious acute respiratory syndrome (SARS) and potential increase in the expression of the angiotensin 2 converting enzyme (ACE2), an enzyme that participates in the process of entrance of the virus into the organism. The gene discussed is ACE2; the disease is obesity due to melanocortin 4 receptor deficiency.