METTL3 and amyotrophic lateral sclerosis: In support of this, it has recently been reported that the depletion of Mettl3 in cholinergic neurons can induce ALS‐like phenotype in mice, and that TDP43 is under the epitranscriptomic control of m6A modification,45 which further substantiates the involvement of m6A genes in ALS pathogenesis.