Alternatively, given that neuronal–glial cell crosstalk is recognized as a critical factor in the pronounced neurotoxicity elicited by TDP43,60 the use of multicellular in vitro models employing motor neurons and microglia derived from CRISPR‐Cas9‐generated iPSCs with RBMX knockout could yield additional insights into the pathophysiology of ALS. This evidence concerns the gene RBMX and amyotrophic lateral sclerosis.