YTHDC2 and amyotrophic lateral sclerosis: The visual representation displayed in Figure 1A revealed that the most frequently mutated genes in patients with ALS were IGF2BP2 (36%) and HNRNPC (26%), followed by YTHDC1 (8%), KIAA1429 (7%), YTHDC2 (7%), RBM15B (7%), RBMX (6%), and ZC3H13 (5%).