Given that the diminution of TBK1 kinase activity in CNS cells may contribute to neurodegeneration through compromised autophagy,55 mitophagy,56 endosomal pathway,57 and membrane trafficking,58 RBMX may participate in ALS pathogenesis by disturbing TBKBP1 expression. This evidence concerns the gene RBMX and amyotrophic lateral sclerosis.