Among these changes were instances of skipping on TIA1 exon 5 and differential expression of several known ALS‐associated genes (e.g., FUS, TBK1, VCP, SQSTM1, and KIF5A) and genes encoding ALS biomarkers, such as neurofilament polypeptides. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.