further subdivided duct‐like cells populations into intercalated ductal‐like cells (KRT19+/AQP5+/KIT+) and duct‐like cells (KRT19+/AQP5−/KIT−), with intercalated ductal‐like cells showing direct relevance to tumor development, participating in NOTCH‐ and MYC‐signaling‐driven tumor proliferation and differentiation pathways, and involvement in immune responses. This evidence concerns the gene AQP5 and neoplasm.