By establishing Catboost model, our study demonstrated that 12 features, including Age, B symptom, Extranodal involvement, ECOG, IPI, Edema/Serous effusion, ALC, AEC, ALB, GLB, LDH, and Chidamide, were significantly related with 2-year OS of AITL patients. This evidence concerns the gene ALLC and angioimmunoblastic T-cell lymphoma.