,92,148 Conversely, the inhibition of MDM2 up-regulates the expression of IL-15, MHC-II, and tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2 in acute myelogenous leukemia cells and activates CD8+ T cells and NK cells, which enhances the anti-tumor effects of T cells within the TME.50 The gene discussed is MDM2; the disease is neoplasm.