Multiple experiments have shown that MDM2 peptides bound to MHC molecules are lifted to T cells by DC antigens, further inducing CD8+/CD4+ cytotoxic T lymphocyte activation.90, 91, 92 In chronic lymphocytic leukemia, the MDM2-derived peptide MDM281-88 has been shown to elicit an autonomous immune response in CD8+ T cells.90 Here, MDM2 is linked to B-cell chronic lymphocytic leukemia.