Wang et al compared the tumor tissues of patients with MDM2 mutations with those of patients without the mutation using next-generation sequencing and found that CD8+ T cells, CD68+ HLA-DR-M1 macrophages, CD68+ HLA-DR-M2 macrophages, and CD56bright and CD56dim NK cells were reduced to different degrees, with CD56dim NK cells showing the greatest difference.179. The gene discussed is MDM2; the disease is neoplasm.