Bao et al. demonstrated that soy isoflavone successfully decreased AHR, airway remodeling, mucus hypersecretion, MMP-9 expression in the lung tissues, pulmonary eosinophilia, pathologic oxidizing process, and Th2 cytokine production induced by OVA in a mouse asthma model [235]. The gene discussed is MMP9; the disease is asthma.