In a clinical study, Gu et al. disclosed that hesperetin inhibits the maturation and function of monocyte-derived dendritic cells from patients with asthma by suppressing the activation of NF-κB, reducing IL-4, increasing IFN-γ levels [45], ameliorating airway inflammation, remodeling, and decreasing airway fibrosis and mucus plug formation [257]. The gene discussed is IFNG; the disease is asthma.