Administration of Crataegus pinnatifida ethanolic extract at concentrations of 100 and 200 mg/kg in the murine asthma model significantly reduces inflammatory cells, especially eosinophils in the lung tissue and BALF and decreases AHR, OVA-specific IgG levels, OVA-specific IgE, and total IgE in the serum and also eotaxin, IL-13, IL-5, and IL-4 after OVA challenge in BALF in comparison with montelukast (30 mg/kg). This evidence concerns the gene AHR and asthma.