For example, in hepatocellular carcinoma, over-regulated Morrbid upregulates the classical EMT-associated transcription factors: Slug, Snail, and Twist1, which transcriptionally activate N-cadherin and vimentin while repressing E-cadherin expression [6,[23], [24], [25], [26]]. Here, MIR4435-2HG is linked to hepatocellular carcinoma.