MIR4435-2HG and hepatocellular carcinoma: For instance, Morrbid binds to the promoter of PIK3CA in the nucleus to enhance its transcription and interacts with miR-150 to upregulate GRB2-associated binder 1 (GAB1) expression, which increases the phosphorylation of ERK1/2 and AKT in hepatocellular carcinoma [3,34].