MMPs, along with VEGF, contribute to tumor angiogenesis, while TGF-β attenuates antitumor immune response by inducing the differentiation of neutrophils into tumor-promoting N2 neutrophils [50,51], inhibiting CD8+ T cytotoxicity, and enhancing the activity of regulatory T cells (Treg) [52]. The gene discussed is CD8A; the disease is neoplasm.