Asparagus polysaccharide induces apoptosis of MDSCs isolated from the spleens of colon cancer mice in a toll-like receptor 4 (TLR4)-dependent manner, after treatment with asparagus polysaccharide for 48 h, the percentage of viable cells decreased from 92.7 in the control samples to 79.8 %. This evidence concerns the gene TLR4 and malignant colon neoplasm.