MAPT and Alzheimer disease: In addition, we also measured the expression of tau in the brain of mice, and we found that the expression of total tau did not change in all groups of mice (Figure 5E), and the expression of p-tau was up-regulated (P = 0.0460 for WT or P = 0.0083 for 3 × Tg-AD; Figure 5F), the ratio of p-tau to tau was also increased in 3 × Tg-AD+OVX mice compared to 3 × Tg-AD mice (Figure 5G).