We also measured the expression of Bcl-2 and Bax in the hippocampus of mice, and we found that the expression of Bcl-2 was down-regulated and Bax expression was up-regulated of 3 × Tg-AD+OVX mice compared to 3 × Tg-AD mice (P = 0.0080 for 3 × Tg-AD; Figures 6E, F). Here, BAX is linked to Alzheimer disease.