Our results showed that the expression of Glu receptors (AMPAR, NMDAR2A and NMDAR2B) in the hippocampus of 3 × Tg-AD+OVX mice was down-regulated to different degrees compared to 3 × Tg-AD mice (P < 0.001 for Figure 8B, P = 0.0072 for Figure 8E, P = 0.0428 for Figure 8G; Figures 8A, B, D–G) and Glu concentration of 3 × Tg-AD+OVX mice was increased (P = 0.0021; Figure 8J). The gene discussed is GRIN2A; the disease is Alzheimer disease.