Previous studies have pointed out that the expression of EAATs was affected by estrogen and Aβ (Lee et al., 2009; Tong et al., 2017), and we demonstrated that the expression of EAAT1 and EAAT2 was down-regulated in the brains of 10-month-old 3 × Tg-AD+OVX mice. Here, SLC1A3 is linked to Alzheimer disease.