Although the density of somatic puncta varied across individual cells, we did not detect any difference in mean density from CA1 Pyr neurons from APP/PS1 and wild-type animals (WT 0.83 ± 0.12 vs. AD 0.90 ± 0.06 puncta/μm2, p = 0.585). This evidence concerns the gene PSEN1 and Alzheimer disease.