As our meta-analysis showed the strongest impact in the stratification of OS patients from HPV positive HNSCC, we decided to explore JUNB, FOS, and FOSB expression levels in 4 different co-culture combinations of human HPV positive HNSCC cell lines, SCC154, and SCC47, and human oral CAFs, OCAF1, and OCAF2. This evidence concerns the gene FOS and head and neck squamous cell carcinoma.