Importantly, HB-EGF treatment in cancer cells and CAFs mono-cultures shows that: LIF is strongly upregulated only by CAFs, indicating that these are the cells responsible for its production when in co-culture (Figure S9A); CSF2 was upregulated by HB-EGF treatment both in cancer cells and in CAFs (Figure S9A). This evidence concerns the gene GSTM1 and cancer.