As our meta-analysis showed the strongest impact in the stratification of OS patients from HPV positive HNSCC, we decided to explore JUNB, FOS, and FOSB expression levels in 4 different co-culture combinations of human HPV positive HNSCC cell lines, SCC154, and SCC47, and human oral CAFs, OCAF1, and OCAF2. Here, JUNB is linked to head and neck squamous cell carcinoma.