This finding applied to the values of the inflammatory factors as well as the serum concentrations of anti-CCP, CRP, RF, and ESR in patients with RA with HAD (28.9 ± 10.5 IU/mL, 19.305 ± 12.6 mg/dl, 20.1 ± 10.1 IU/mL and 52.12 ± 18.09 mm/h, respectively), which were higher than those in patients with LDA and MDA (P = 0.0001), as indicated in Table 3. The gene discussed is CRP; the disease is rheumatoid arthritis.