Functional characterization of HCC cell proliferation demonstrated that inhibitor 7, exhibiting the highest IC50 of 63.31 μM for TRPM7, decreased cell proliferation only marginally, whereas all others caused growth arrest in HuH7 and HuH6 cells (Figures 1D, 1E, S1A, and S1B). Here, TRPM7 is linked to hepatocellular carcinoma.