GCG and heart failure: Additionally, GLP-1 RAs significantly reduced the risk of hospitalization for heart failure by 10% (HR: 0.90; 95% CI: 0.82-0.99; P = 0.023) and provided robust benefits in reducing the incidence of macroalbuminuria by 26% (HR: 0.74; 95% CI: 0.67-0.82; P < 0.001) [24].