Patients underwent a 4-month EXE regimen with adherence tracking, alongside baseline and endpoint clinical and biochemical evaluations encompassing serum testosterone, SHBG, FAI, lipid profile, insulin resistance, and liver function. Endothelial function was gauged via RH-PAT, while clot structure and fibrinolysis were analyzed using turbidity and lysis assays. Here, SHBG is linked to Insulin resistance.