Fucoidan was also shown to induce the expression of cluster of differentiation 40 (CD40), CD80, and CD86 for producing the interleukin-6 (IL-6), IL-12, and tumor necrosis factor-alpha (TNF-α) in spleen conventional dendritic cells (CDCs) in mice challenged with murine tumor cell in skin (B16-OVA) tumor cells. The gene discussed is TNF; the disease is neoplasm.