In line with these findings, our study detected significant increases in GRO/KC, IL‐18, MCP‐1, and TNF‐α levels in rats' PB under SMG (Figure 4a–d), these cytokine/chemokine mediate inflammation, immune diseases, and metabolic diseases (Dinarello et al., 2013). This evidence concerns the gene CXCL1 and metabolic disease.